Cardiac Remodeling During the Morphogenesisof Neuroleptic Cardiomyopathy by Volkov VP in
Advancements in Cardiovascular Research (ACR) in Lupine Publishers
Introduction: A neuroleptic cardiomyopathy NCMP belongs to
secondary specific metabolic dilated cardiomyopathies. It is
caused by side cardiotoxic effect of antipsychotic preparations. In its
development NCMP passes three clinical stages: 1) latent, 2)
developed and 3) terminal.
Aim: A morphometric study of the macroscopic heart condition in each clinical stage of NCMP
Material and methods: The autopsy protocols of 80 dead persons with NCMP in various stages and of 100 persons who did
not have any accompanying cardiac pathology were studied. For analysis of the received data the original author’s method that we
had developed for such studies was used.
Results: All macroscopic cardiac parameters in the case of NCMP statistically significantly differ from normal one, but no
significant differences in various clinical stages of NCMP.
Conclusion: The process of cardiac remodeling on the organ level ends during the latent stage of the disease. Progression of
myocardial dysfunction is connected with changes of myocardium microstructure.
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