Wednesday, January 30, 2019

Cardiology-journal_Lupine Publishers

Plenty has been written about the impact of arteriosclerosis, i.e. arterial biomineralization, on the functioning of human body. A little less information is available concerning the dissolution and prevention of such mineralization (calcium channel blockers etc.) [1,2]. The significance of even a small progress in “cleaning” the arteries cannot be overstated. By renewing the proper functioning of the cardiovascular system, it will restore proper functioning of tissue, organs, and other elements of the body, and in effect support removal or reduction of many diseases. It will lead to lasting rejuvenation of the body.

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Wednesday, January 23, 2019

HTLV-1 Seropositivity and Unexplained Dilated Cardiomyopathy in Jamaican Patients: (ACR) - Lupine Publishers

Background: Viruses have been implicated in the aetiology/pathogensis of unexplained dilated cardiomyopathy. 6% of adult Jamaicans are HTLV-1 seropositive. We therefore explored the relationship between HTLV-1 infectious cases and unexplained dilated cardiomyopathy in Jamaica.
Methods: Thirteen patients were recruited from Kingston Public Hospital Cardiology clinic, to study HTLV-1 seroprevalence in patients with unexplained dilated cardiomyopathy (WHO criteria: LVEF< 45 %, LVIDd>117% of upper limit for age and BSA without evidence of coronary disease, severe hypertension, excess alcohol intake, valvular heart disease and HIV infection). The HTLV-1 seroprevalence in a group of patients without dilated cardiomyopathy registered in the cardiology clinic was then compared. HTLV- 1 antibodies were detected by ELISA and confirmed where positive by Western Blot. Logistic regression was used to assess the association between HTLV-1 seropositivity and unexplained dilated cardiomyopathy.
Results: HTLV1 seroprevalence in 11 patients (7 males, 3 females) with unexplained dilated cardiomyopathy and 30 (11 males, 19 females) controls were compared. Three (27%) patients with cardiomyopathy and 3 (10%) of controls had HTLV-1 antibodies the crude OR (95%CI) for HTLV1 seropositivity was 3.36 (0.57-20.10). The age and sex adjusted OR (95%CI) was 2.71(0.43-17.19).
Conclusion: There may be an association between HTLV-1 infection and unexplained dilated cardiomyopathy in Jamaica. A larger study is required to further explore this potential relationship.

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Wednesday, January 16, 2019

Extracorporeal Membrane Oxygenation for Failed TPA Therapy of Pulmonary Embolism: (ACR) - Lupine Publishers

Pulmonary embolism may cause cardiac arrest secondary to obstruction of blood flow. Traditional treatment strategies include anticoagulation, thrombolysis, and mechanical extraction. Some advocate for support with extra corporeal membrane oxygenation (ECMO); however, surgical therapies are contraindicated following thrombolytics. We describe the emergent use of peripheral ECMO following thrombolytic therapy for a saddle pulmonary embolism associated with multiple episodes of cardiac arrest. The patient was stabilized with peripheral ECMO, anticoagulated and subsequently weaned from ECMO without any major bleeding complications. The administration of thrombolytics should not be a contraindication for ECMO in patients with massive pulmonary embolism associated with hemodynamic instability.

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Wednesday, January 9, 2019

Cardiac Remodeling During the Morphogenesis of Neuroleptic Cardiomyopathy: (ACR) - Lupine Publishers

Cardiac Remodeling During the Morphogenesisof Neuroleptic Cardiomyopathy by Volkov VP in
Advancements in Cardiovascular Research (ACR) in Lupine Publishers 

Introduction: A neuroleptic cardiomyopathy NCMP belongs to secondary specific metabolic dilated cardiomyopathies. It is caused by side cardiotoxic effect of antipsychotic preparations. In its development NCMP passes three clinical stages: 1) latent, 2) developed and 3) terminal.
Aim: A morphometric study of the macroscopic heart condition in each clinical stage of NCMP
Material and methods: The autopsy protocols of 80 dead persons with NCMP in various stages and of 100 persons who did not have any accompanying cardiac pathology were studied. For analysis of the received data the original author’s method that we had developed for such studies was used.
Results: All macroscopic cardiac parameters in the case of NCMP statistically significantly differ from normal one, but no significant differences in various clinical stages of NCMP.
Conclusion: The process of cardiac remodeling on the organ level ends during the latent stage of the disease. Progression of myocardial dysfunction is connected with changes of myocardium microstructure.
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Cardiology-journal_Lupine Publishers

Problems of Biomineralization Dissolution inHuman Arteries by Maciej Pawlikowski in Advancements in Cardiovascular Research (ACR) ...