Neuroleptic Cardiomyopathy and Myocardial Hibernation by VP Volkov in Advancements in Cardiovascular Research in Lupine Publishers
Aim: It is to summarize and in a new way to interpret the data, which have been earlier received, in order to prove the
development of the hibernation of myocardium (HM) in cases of the neuroleptic cardiomyopathy (NCMP).
Methods and results: Morphometric methods of research were
used which meet modern requirements of the evidence-based
medicine. The studied micro morphometric parameters describe the
condition of three structural components of myocardium
(vasculature, intercellular matrix, and parenchyma). Such parameters as
zone of pericapillary diffusion (ZPD), Kernogan index
(KI), SPR, RIE were calculated. Karyometry and cytometry of
cardiomyocytes (CMCs) were performed, the specific volumes of
hypertrophied CMCs (SVHC), of atrophied ones (SVAC), and – by the method
of polarization microscopy – the specific volume of
dystrophic ones (SVDC) were determined. When NCMP is absent, the
changes, which have an acute character, develop in the case of
SCD and NMS and reflect the statistically significant shifts of the
respective quantitative parameters. When NCMP is present, the only
parameter, which is significantly changed in connection with SCD and
NMS, is SVDC.
Conclusion: NCMP causes irreversible damages in myocardium, it leads to its are activity, practically almost fully prevents it
from reacting to any influences, particularly to the coming of SCD and/or development of NMS. The found morpho functional state
of cardiac muscle in the case of NCMP is an independent proof of state of HM which appears during the process of morphogenesis
of NCMP.
For more Lupine Publishers Open Access Journals Please visit our website
For more Cardiology Open
Access Journal articles Please Click
